- Matilda as Lisa Simpson
- Miss Honey as Stan Marsh
- Bruce Bogtrotter as Yo
- Lavander as Allison Taylor
- Hortensia as Numbuh 2
- Amanda Thripp as Noddy
- Mrs. Thelps as Ten Cents
- Miss Trunchbull as Eric Cartman
- Cookie as Jack Spicer
- Harry Wormwood as Shelly Marsh
- Zinnia Wormwood as Harley
- Mike Wormwood as Numbuh 86
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