The video for the album's first single, "Make It Rain," was shot and featured on BET Access Granted on September 27, 2006.  The second single was No Drama (Clap & Revolve), produced by The Runners.
Me, Myself & I debuted at number 14 on the U.S. Billboard 200, selling about 60,000 copies in its first week. This was also the album's peak on the chart. It also debuted and peaked at number three on the Top R&B/Hip-Hop Albums and number two on the Top Rap Albums charts. There was a remix to Make It Rain, featuring Lil Wayne, T.I., Rick Ross, R Kelly, Baby (rapper), Ace Mack, and DJ Khaled.
|1||"Pandemic"||Streetrunner||Cartagena, J./Warwar, N.||3:25|
|2||"Damn"||LV for The Hitmen||Cartagena, J./Coppin, L./Hanson, B.||3:50|
|3||"The Profit"||DJ Khaled||Lil Wayne||Cartagena, J./Khaled, K./Carter, D.||5:07|
|4||"No Drama (Clap & Revolve)"||The Runners||Cartagena, J./Harr, A./Jackson, J.||3:58|
|5||"Breathe and Stop"||Nu Jerzey Devil||The Game||Barrett, C./Cartagena, J./Taylor, J./Torres, A./Allen, C.||3:44|
|6||"She's My Ma"||Streetrunner||H-Mob||Cartagena, J./Douglass, J./Easterling, H./Goldsmith, L./Warwar, N./Thompson, R.||4:23|
|7||"Make It Rain"||Scott Storch||Lil Wayne||Cartagena, J./Storch, S./Carter, D.||4:11|
|8||"Jealousy"||LV for The Hitmen||Cartagena, J./Coppin, L./Hayes, I.||4:55|
|9||"Think About It"||Scott Storch||Cartagena, J./Storch, S.||3:31|
|10||"Hard Not to Kill"||LV for The Hitmen||Cartagena, J./Coppin, L./Gaye, M.||2:55|
|11||"Bendicion Mami"||Streetrunner||Brown, L./Cartagena, J./Glover, L./Gordy, H./Story, A./Warwar, N.||4:41|
|12||"Story to Tell"||DJ Khaled||Cartagena, J./Khaled, K.||5:17|
- Make It Rain containing Lil' Wayne verse.
- We Takin' Over featuring Rick Ross & Akon. (Given to DJ Khaled for his album We the Best).
- Money, Money, Money (Still remains unreleased)
<ref>tags exist, but no
<references/>tag was found