• Kevin as Homer
  • Mark as Marge
  • Stuart as Bart
  • Jorge as Lisa
  • Agnes (from Despicable Me) as Maggie
  • Gru as Grandpa Abe
  • Bob as Krusty the Clown
  • Tom as Ned Flanders
  • Margo (from Despicable Me) as Maude Flanders
  • Dave and Jerry as Lenny and Carl
  • Tim as Moe
  • Phil as Barney
  • Herb as Mr. Burns
  • Mr. O'Hare (from Dr. Seuss' The Lorax) as Mr. Smithers
  • Mr. Bunny (from Hop) as Prinicpal Skinner
  • Scarlet as Enda Krabappel
  • Eduardo (from Despicable Me 2) as Superintendent Chalmers
  • The Once-ler's Dad (from Dr. Seuss' The Lorax) as Groundskeeper Willie
  • Ted (from Dr. Seuss' The Lorax) as Milhouse
  • The Lorax (from Dr. Seuss' The Lorax) as Chief Wiggum
  • Old Once-ler (from Dr. Seuss' The Lorac) as Mayor Quimby
  • T-Rex as Sideshow Bob
  • E.B. (from Hop) as Reverend Lovejoy
  • Audrey (from Dr. Seuss' The Lorax) as Helen Lovejoy
  • Dr. Nefario (from Despicable Me) as Dr. Hibbert
  • Vector (from Despicable Me) as Johnny Tightlips

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