- John Smith as Kermit the Frog
- Jane Smith as Miss Piggy
- Eddie as The Swedish Chef
- Benjamin Danz as Beaker
- Jasmine as Janice
- Father as Sweetums
- Martin Coleman as Dr. Bunsen Honeydew
- Suzy Coleman as Annie Sue Pig
- Gwen as Ma Bear
- Julie as Foo-Foo
- Jade as Miss Mousey
- Dr. Wexler as Uncle Deadly
- Mr. Smith's Boss as Camilla the Chicken (voice) (uncredited)
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