• Mr. Peabody as Thomas
  • Sherman as Percy
  • Horton (from Horton Hears a Who) as Edward
  • George (from George of the Jungle) as Henry
  • Moe (from The Simpsons) as Gordon
  • Homer Simpson (from The Simpsons) as James
  • Destiny (from Mongrels) as Emily
  • Penny Peterson as Rosie
  • Paul Peterson as Diesel

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