• Lawrence Fletcher as Gru
  • Star Butterfly as Margo
  • Penny Sanchez as Edith
  • Ashley (Clarence) as Agnes
  • TBA as Lucy Wilde
  • TBA as Eduardo "El Macho" Pérez
  • TBA as Dr. Nefario
  • TBA as Floyd Eagle-san
  • TBA as Silas Ramsbottom

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