- Kermit the Frog as Homestar Runner (Kermit and Homestar are both the lead character)
- Sam the Eagle as Strong Bad (Sam and Strong Bad are both grumpy)
- Rizzo the Rat as The Cheat (Rizzo and The Cheat are both small)
- Sweetums as Strong Mad (Sweetums and Strong Mad are both tall)
- Droop as Strong Sad (Droop and Strong Sad are both sad)
- Beaker as Pom Pom (Beaker and Pom Pom both speak a different language)
- Miss Piggy as Marzipan (Miss Piggy and Marzipan are both girlfriends to Kermit and Homestar)
- Gonzo as Coach Z (Gonzo and Coach Z are both weird)
- Pepe the King Prawn as Bubs (Pepe and Bubs both have orange in them)
- Zoot as The King of Town (Zoot and The King of Town are both greedy)
- Lips as The Poopsmith (Lips and The Poopsmith are both silent)
- Fozzie Bear as Homsar (Fozzie and Homsar are both silly)
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