- Numbuh 3 as Cruella De Vil
- Bill and Ben as Jasper and Horace
- Fireman Sam as Pongo
- Noddy as Perdita
- Ten Cents (from TUGS) as Roger
- Lillie Lightship (from TUGS) as Anita
- Numbuh 5 as Nanny
- Wallace as Sgt. Tibbs
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