Cast[]
- Little Bill as Yakko Warner
- Wubbzy as Wakko Warner
- Dora as Dot Warner
- Puddle as Pinky
- Toot as Brain
- Mami (Dora the Explorer) as Hello Nurse
- Big Bill as Dr. Scratchansniff
- Mr. Rojas as Ralph the Guard
- Ye-Ye (Ni Hao, Kai-Lan) as Thaddeus Plotz
- Linda as Phar Fignewton
- Mama Jaguar as Slappy Squirrel
- Baby Jaguar as Skippy Squirrel
- Gil as Squit
- Goby as Pesto
- Nonny as Bobby
- Mr. Grouper as Solley the Godpigeon
- Lito (Little Bill) as Buttons
- Paprika as Mindy
- Mrs. Pepper as Mindy's Mother
- Mr. Salt as Mindy's Father
- Isa as Rita
- Benny as Runt
- Alicia as Minerva Mink
- Sammy as Newt
- Uncle Al as Flavio
- Aunt Vanessa as Marita
- Norville as Chicken Boo
- Zeg as Mr. Skullhead
- Stripes as Mime
- Pinky Dinky Doo as Katie Ka-Boom
- Tyler Dinky Doo as Tinker Ka-Boom
- Mommy Dinky Doo as Mrs. Ka-Boom
- Daddy Dinky Doo as Mr. Ka-Boom
- Ferocious Beast as Baloney
- Daisy (Oswald) as Mary Hartless
- Miss Murray as Miss Flamiel
- King Juan El Bobo as Mr. Director
- Al Glover as Pip Pumphandle
- Petunia (Dora the Explorer) as Billie
- Russian Troll (Dora the Explorer) as Snowball
- Mr. Mole as Walter Wolf
- Bill Buffalo (Franklin) as Beanie the Brain-Dead Bison
- Coyote (Franklin) as Sid the Squid
- Mole (Franklin) as Stephen Wolf
- Tico as Charlton Woodchuck
- Baby Huffington as Birdie
- Molly as Sasha
- Deema as Kiki
- Ooma as Lana
- Officer Miranda (Bubble Guppies) as Molly
- Farmer Joe (Bubble Guppies) as Steven Seagull
- Bot (Team Umizoomi) as Pipsqueak
- Mayor Goodway as Dr. Gina Embryo
- Val the Octopus as Maid
- Ryder as Wilford B. Wolf
- Steve (Blue's Clues) as Steven Spielberg
- Joe (Blue's Clues) as Bill Clinton
- Hamilton as Neivel Nosenest
- El Mago (Dora the Explorer) as Mr. Flaxseed
- Dr. Ha Song (Toot and Puddle) as Wally Llama
- Big Red Chicken as Death
- Shimmer and Shine as Survey Ladies
- Bud (Dora the Explorer) as Flame
- Snail (Franklin) as Colin
- Shovel as Moth
- Pail as Butterfly
- Mr. Porter as Stinkbomb D. Bassett
- Alex Porter as Bumpo Bassett
- Mitzi (Little Bear) as Candie Chipmunk
- Crusher as Doug the Dog
- Lilly (Toot and Puddle) as Carloota
- No Feet (Little Bear) as Prettyboy Robin
- Bobo Brothers as Cawcaw and Charlie
- Pirate Pig as Noodles
- Pirate Piggies as Noodles' Sparrows
- Alice the Great as World's Oldest Woman
- Mayor Humdinger as King Salazar
- Foggy Bottom Boomers as Salazar's Soldiers
- Kitten Catastrophe Crew as Salazar's Dogs