• Rhonda Lloyd (from Hey Arnold) as Cady Heron
  • Trixie Tang (from The Fairly OddParents) as Regina George
  • Kimi Finster (from Rugrats) as Janis Ian
  • Sandy Cheeks (from SpongeBob SquarePants) as Gretchen Weiners
  • Leni Loud (from The Loud House) as Karen Smith
  • Tommy Pickles (from Rugrats) as Aaron Samuels
  • Chuckie Finster (from Rugrats) as Damian
  • Mr. Neutron (from Jimmy Neutron) as Mr. Ron Duvall
  • Carl Wheezer (from Jimmy Neutron) as Jason