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- Larry Daley as Wade
- Ameila Earhart as Brianna
- Ellie (from Ice Age: The Meltdown) as Wade's Mom
- Octavious as Wade's Dad
- Sacagawea as Mimi
- Mona (from The Simpsons) as Mrs. Mulcrone
- Head Elf (from Rudolph the Red Nosed Reindeer) as Mr. K
- General Custer as Zackary
- Theodore Roosesavelt as Zeke
- Manny (from Ice Age) as Mr. Cummings
- Jebeidiah as Uncle Ed
- Al Capone as Hitler
- Bumble the Abominable Snow Monster (from Rudolph the Red Nosed Reindeer) as Yeti (as seen in Disney's Expedtion Everest)