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Powerpuff Girls/101 Dalmatians are parodies with 101 Dalmatians sounds and Powerpuff Girls clips.
- Brick as Pongo
- Blossom as Perdita
- The Mayor as Roger
- Sara Bellum as Adnita
- Buttercup as Nanny
- Sedusa as Cruella De Vil
- Den (from Thomas & Friends) as Jasper
- Dart (from Thomas & Friends) as Horace
- Snake as Patch
- Big Billy as Rolley
- Ace as Lucky
- Skinny Slim as Captain
- Bossman as Colonel
- Professor Utonium as Sgt. Tibbs
- Boomer as Towser
- Bubbles as Lucy
- Butch as Thunderbolt