- Patti as Sarah Hall-Small
- Dana as Cindy Lou Who
- Ben as The Cat in the Hat
- Jack Marshall as Mack the Turtle
- Curt as Sam-I-Am
- The Maestro as Horton the Elephant
- Amanda Rawlings as Dr. Amanda Rebecca
- Bobbie Sue as Jillian
- Scott as The Lorax
- Shirley as Daisy-Head Mayzie
- Edna as Audrey
- Reeves as Joey
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