- Ramona Quimby as Muffy
- Beezus Quimby as Francine
- Henry Huggins as Arthur
- Aunt Bea as D.W.
- Robert Quimby as Mr. Haney
- Dorothy Quimby as Ms. Tingley
- Hobart as David
- Howie Kemp as Buster
- Mrs. Meacham as Jane
- Roberta Quimby as Nadine Flumberghast
- Susan Kushner as Molly
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