- Ramona Quimby as Annie
- Beezus Quimby as Petunia Rhubarb
- Henry Huggins as Bob
- Robert Quimby as Junior
- Dorothy Quimby as Laura
- Hobart as Archibald Asparagus
- Howie Kemp as Larry
- Mrs. Meacham as Mom
- Roberta Quimby as Madame Blueberry
- Susan Kushner as Bad Apple
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