- Riddick as Homer Simpson
- Colonel R. "Boss" Johns as Mayor Joe Quimby
- Santana as Mr. Burns
- Dahl as Lisa Simpson
- Diaz as Bart Simpson
- Moss as Principal Seymour Skinner
- Lockspur as Waylon Smithers, Jr.
- Vargas as Moe Syzlak
- Luna as Ned Flanders
- Falco as Grandpa Abe Simpson
- Nunez as Barney Gumble
- Rubio as Milhouse Van Houten
- Siberius Vakko as Chief Clancy Wiggum
- Lex Branman as Dr. Julius Hibbert
- Krone as Ralph Wiggum
- Santana's Prisoner as Edna Krabappel
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