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- Scooby Doo as Tommy
- Shaggy as Chuckie
- Fred as Drew
- Daphne as Didi
- Lena Dupree as Kimi Finster
- Scrappy Doo as Dil Pickles
- Scooby Dum as Lil DeVille
- Buttercup (Powerpuff Girls) as Phil DeVille
- Villian as Reptar