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- Zoe as Mama Mousekewitz
- Stan Marsh (from South Park) as Papa Mousekewitz
- Miss Piggy as Tanya Mousekewitz
- Elmo as Fievel Mousekewitz (Dr. Facilier can't be Fievel Mousekewitz because Dr. Facilier is bad and Fievel Mousekewitz is good)
- Duck (from Thomas and Friends) as Henri
- Dr. Facilier (from The Princess And The Frog) as Warren T. Rat (Elmo can't be Warren T. Rat because Elmo is good and Warren T. Rat is bad)
- Chief Wiggum (from The Simpsons) as Digit
- Murray as Moe (they both start with m)
- Bart (from The Simpsons) as Tony Toponi
- Marge (from The Simpsons) as Bridget
- Milhouse (from The Simpsons) as Honest John
- Susan as Gussie Mausheimer
- Dennis (from Thomas and Friends) as Tiger (they both lazy and greedy)