- John Shaft as Ash Ketchum
- Carmen Vasquez as Dawn
- Peoples Hernandez as Brock
- Walter Wade, Jr. as Professor Birch
- Uncle John as Buizel
- Judge Dennis Bradford as Mewtwo
- Rasaan as Squirtle
- Diane Palmieri as Misty
- Jack Roselli as Tropius
- Jimmy Groves as Pikachu
- Curt Flemming as Gary Oak
- Carla Howard as May
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