- Stan Marsh as Indiana Jones
- Butters Stotch as Henry Jones Sr.
- Kyle Broflovski as Mutt Williams
- Wendy Testaburger as Marion Ravenwood
- Eric Cartman as Willie Scott
- Kenny McCormick as Short Round
- Chef as Sallah
- Sheila Broflovski as Elsa Schneider
- Shelly Marsh as Irina Spalko
- Gregory Of Yardale as Rene Belloq
- Bebe Stevens as Lao Che
- Satan as Mola Ram
- Scott The Dick as Arnold Ernst Toht
- Scott Tenorman as Colonel Dietrich
- Saddam Hussian as Colonel Vogel
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