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South Park/Scooby Doo are parodies with Scooby Doo sounds and South Park clips.
- Mr. Garrison as Fred
- Wendy Testaburger as Daphne (Wendy Testaburger and Daphne Blake are both Formerly Voiced By Mary Kay Bergman)
- Bebe Stevens as Velma
- Stan Marsh as Shaggy
- Kenny McCormick as Scooby Doo
- Butters Stotch as Scrappy Doo
- Craig Tucker as Scooby-Dum
- Eric Cartman as Stan Laurel
- Harold Cartman as Oliver Hardy
- Clyde Donovan as Moe Howard
- Tweek Tweak as Larry Fine
- Timmy as Curly Howard
- Chef as Batman
- Kyle Broflovski as Robin
- Father (from Codename: Kids Next Door) as Joker
- Heinrich Von Marzipan (from Codename: Kids Next Door) as Penguin
- Luke Skywalker as Davy Jones
- Satan as The Phantom Virus