• Jo Frost as Mrs. Frizzle
  • Pierce Park as Liz
  • Frank Patrick Minyon as Arnold
  • Emma Van Acker as Wanda
  • Dylan Van Acker as Ralphie
  • Jonathon Addis as Carlos
  • Jordon Hallenbeck as Tim
  • Mary-Anne Agate as Keesha
  • Farley Park as Dorothy Ann
  • Eden Addis as Phoebe
  • Skyler Minyon as Janet
  • Jo's Car as The Bus
  • Corey Christiansen as Mr. Ramon

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