- Horrid Henry (from Horrid Henry) as Carl Fredricksen
- Elmo St. Peters (from The Brave Little Toaster) as Russell
- Shrek (from Shrek) as Charles Muntz
- Molly (from Thomas and Friends) as Kevin
- Larry (from Rugrats) as Dug
- Homer (from The Simpsons) as Alpha
- Steve (from Rugrats) as Beta
- Arthur (from Arthur) as Gamma
- Woody (from Toy Story) as Young Carl
- Angelica (from Rugrats) as Young Ellie
- Rhonda (from Hey Arnold) as Ellie Fredricksen
- T.W. Turtle (from Cats Don't Dance) as Construction Foreman Tom
- Thomas (from Thomas and Friends) as Construction Worker Steve
- Larry (from Rugrats) as Nurse George
- Steve (from Rugrats) as Nurse A.J.
- Police Officer (from Over the Hedge) as Police Officer Edith
- Ogre Babies (from Shrek) as The Other Dogs
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