- Kenneth James Kitsom as Solid Snake
- Dr. Marta Shearing as Meryl Sliverburgh
- Eric Buyer as Fatman
- CIA Deputy Director Pamela Landy as Mei Ling
- Terrence Ward as Revolver Ocelot
- Mark Turso as Vamp
- Dr. Donald Foite as Scott Dolph
- LARX-03 as Sergei Gurlukovich
- and more
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