- Kenneth James Kitsom as Captain Jack Sparrow
- Dr. Marta Shearing as Anamaria
- Eric Buyer as Captain Barbossa
- CIA Deputy Director Pamela Landy as Elizabeth Swann
- Terrence Ward as Will Turner
- Mark Turso as Governor Weatherby Swann
- Dr. Donald Foite as Joshamee Gibbs
- LARX-03 as Jolly Roger
- and more
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