- Jason Bourne as Homer Simpson
- Nicolette "Nicky" Parsons as Marge Simpson
- Noah Vosen as Mr. Burns
- Ezra Kramer as Bart Simpson
- Simon as Grandpa Abe Simpson
- Paz as Dr. Julius Hibbert
- Dr. Albert Hirsch as Ned Flanders
- Pamela "Pam" Landy as Lisa Simpson
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