- Gru (from Despicable Me) as Artie Decker
- Lucy Wilde (from Despicable Me 2) as Diane Decker
- Winnie as Alice Simmons
- Eggs as Phil Simmons
- Lee Kenker (from Ed, Edd, n Eddy) as Harper Simmons
- TJ (from Recess) as Turner Simmons)
- Spinelli (from Recess) as Barker Simmons
- Merida (from Brave) as Cassandra
- Marge Simpson (from The Simpsons) as Dr. Schveer
- The Lorax (from The Lorax) as Mr. Cheng
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