January[]
| Date | Guest | Promotion |
|---|---|---|
| January 4 | ? | |
| January 5 | ? | |
| January 6 | ? | |
| January 10 | Joe Montana | |
| January 11 | Will Ferrell | |
| January 12 | Ice Cube | |
| January 13 | Michael Stipe | |
| January 17 | Penelope Ann Miller | |
| January 18 | Frankie Muniz | |
| January 19 | Freddie Prinze Jr. | |
| January 20 | Jerry Springer | |
| January 24 | Selma Blair | |
| January 25 | Peter Krause | |
| January 26 | Ashley Judd | |
| January 27 | David Arquette |
February[]
| Date | Guest | Promotion |
|---|---|---|
| February 1 | Jeff Bridges | |
| February 2 | Bob Dole | (via satellite) 1-hour special |
| February 14 | Moby | |
| February 15 | Dennis Farina | |
| February 16 | Matthew Perry | |
| February 17 | Ed McMahon | |
| February 22 | Snoop Dogg | |
| February 23 | Charlize Theron | |
| February 24 | Rachael Leigh Cook | |
| February 28 | Forest Whitaker | |
| February 29 | Vin Diesel |
March[]
| Date | Guest | Promotion |
|---|---|---|
| March 1 | Tobey Maguire | |
| March 2 | Ellen DeGeneres | |
| March 6 | Neil Patrick Harris | |
| March 7 | Kevin Pollak | |
| March 8 | Bob Dole | |
| March 9 | Garry Shandling | |
| March 13 | Eddie Izzard | |
| March 14 | Kim Delaney | |
| March 15 | Wolf Blitzer | |
| March 16 | Drew Carey | |
| March 20 | Chris Meloni | |
| March 21 | Marla Sokoloff | |
| March 22 | Eric Idle | |
| March 23 | Leelee Sobieski | |
| March 27 | John Lydon | |
| March 28 | Joshua Jackson | |
| March 29 | Triumph the Insult Comic Dog | |
| March 30 | Jimmy Smits | Price of Glory |
April[]
| Date | Guest | Promotion |
|---|---|---|
| April 10 | Peter Berg | |
| April 11 | Ben Stein | |
| April 12 | Queen Latifah | |
| April 13 | David Alan Grier | |
| April 24 | ? | |
| April 25 | ? | |
| April 26 | ? | |
| April 27 | Stephen Baldwin |
May[]
| Date | Guest | Promotion |
|---|---|---|
| May 1 | S. Epatha Merkerson | |
| May 2 | Luke Wilson | |
| May 3 | Julie Warner | |
| May 4 | Eric Close | |
| May 8 | Wendie Malick | |
| May 9 | Jesse L. Martin | |
| May 10 | Andy Richter | |
| May 11 | Kyle MacLachlan | |
| May 15 | Tracey Ullman | |
| May 16 | ? | |
| May 17 | Jane Leeves | |
| May 18 | Michael Rapaport | |
| May 29 | ? | |
| May 30 | ? | |
| May 31 | ? |
June[]
| Date | Guest | Promotion |
|---|---|---|
| June 1 | Sonja Christopher | |
| June 5 | Penn and Teller | |
| June 6 | Michael Moore | |
| June 7 | Kelsey Grammer | |
| June 12 | When the Elderly Go on TV with Al Greenwood |
|
| June 13 | Mark Curry | |
| June 14 | Bob Dole | |
| June 15 | Julie Brown | |
| June 19 | Toni Collette | |
| June 20 | Joe Lockhart | |
| June 21 | Freddie Prinze Jr. | |
| June 22 | Alicia Silverstone | |
| June 26 | Cheri Oteri | |
| June 27 | Jeff Probst | |
| June 28 | Richie Sambora |
July[]
| Date | Guest | Promotion |
|---|---|---|
| July 10 | Anna Paquin | X-Men |
| July 11 | J. K. Simmons | Oz |
| July 12 | Famke Janssen | X-Men |
| July 13 | Billy Crudup | Jesus' Son |
| July 17 | ? | |
| July 18 | Halle Berry | |
| July 19 | Fourth Anniversary Special | |
| July 20 | Al Roker | |
| July 24 | Peter Fonda | |
| July 25 | Jennifer Beals | |
| July 26 | ? | |
| July 31 | Campaign Trail to the Road to the Whitehouse Mo Rocca, Vance DeGeneres |
August[]
| Date | Guest | Promotion |
|---|---|---|
| August 1 | Republican National Convention coverage |
|
| August 2 | RNC coverage | |
| August 3 | RNC coverage | |
| August 4 | RNC, Peter Jennings | |
| August 15 | Democratic National Convention coverage |
|
| August 16 | DNC coverage | |
| August 17 | DNC coverage | |
| August 18 | DNC coverage | |
| August 22 | Vincent D'Onofrio | |
| August 23 | Slash | |
| August 24 | ? |
September[]
| Date | Guest | Promotion |
|---|---|---|
| September 5 | ? | |
| September 6 | Greg Kinnear | |
| September 7 | ? | |
| September 11 | Joe Mantegna | |
| September 12 | Eugene Levy | |
| September 13 | Lennox Lewis | |
| September 14 | Joe Lieberman | |
| September 18 | Ryan Phillippe | |
| September 19 | Jamie Lee Curtis | |
| September 20 | Barenaked Ladies | |
| September 21 | Jamie Foxx | |
| September 25 | Jonathan Katz | |
| September 26 | ? | |
| September 27 | Sylvester Stallone | |
| September 28 | Tony Danza |
October[]
| Date | Guest | Promotion |
|---|---|---|
| October 2 | Dean Cain | None |
| October 3 | Ashton Kutcher | |
| October 4 | Jewel | |
| October 5 | Ralph Nader | |
| October 16 | ? | |
| October 17 | Christian Slater | |
| October 18 | ? | |
| October 19 | Brendan Fraser | |
| October 23 | Billy Campbell | |
| October 24 | ? | |
| October 25 | Posh Spice & Baby Spice | |
| October 26 | Steven Weber | |
| October 30 | Brett Butler | |
| October 31 | David Frost |
November[]
| Date | Guest | Promotion |
|---|---|---|
| November 1 | ? | |
| November 2 | Michael Richards | |
| November 6 | Arlen Specter | |
| November 7 | Indecision 2000 Choose and Loose |
|
| November 8 | Richard Belzer | |
| November 9 | Michael Moore | None |
| November 13 | Adam Sandler | |
| November 14 | Patricia Arquette | |
| November 15 | Adam Sandler | |
| November 16 | Rhys Ifans | |
| November 20 | Tales of Survival with Vance DeGeneres | |
| November 27 | ? | |
| November 28 | ? | |
| November 29 | ? | |
| November 30 | ? |
December[]
| Date | Guest | Promotion |
|---|---|---|
| December 4 | Thomas Gibson | |
| December 5 | Faith Ford | |
| December 6 | Chris O'Donnell | |
| December 7 | John Goodman | |
| December 11 | Ira Glass | |
| December 12 | Greta Van Susteren | |
| December 13 | Indecision 2000 Special | |
| December 14 | Wolf Blitzer | |
| December 18 | Marla Sokoloff | |
| December 19 | Marisa Tomei | |
| December 20 | Jeri Ryan | |
| December 21 | Gillian Anderson |