- Beth Cappadora as Lois Griffin
- Pat Cappadora as Peter Griffin
- Det. Candy Bliss as Dr. Amanda Rebecca
- Vincent Cappadora as Chris Griffin
- Ben Cappadora as Brian Griffin
- Kerry Cappadora as Meg Griffin
- Jimmy Daugherty as Mort Goldman
- Ellen as Carol Pewterschmidt
- Grandpa Angelo as Cleveland Brown
- Grandma Rosie as Jillian
- George Karras as Dr. Hartman
- Laurie as Olivia Fuller
- Chief Bastokovich as Bruce
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