• Tootie as Brandy Harrington
  • Timmy as Mr. Whiskers
  • Wanda as Lola Boa
  • Cosmo as Ed the Otter
  • Denzel Crocker as Gaspar Le Gecko
  • Trixie Tang as Margo
  • Mr. Horse (from The Ren and Stimpy Show) as Tito the Samba Monkey
  • Thud (from A Bug's Life) and Mr. Krabs (from SpongeBob SquarePants) as The Monkeys
  • Bev Bighead (from Rocko's Modern Life) as Mama Croc
  • Mario (from Super Mario Bros.) as Santa Clause
  • Amy Rose (from Sonic the Hedgehog) as Cheryl
  • Lola Caricola (from CatDog) as Meryl
  • Ren Hoek's Mom (from Ren and Stimpy: Adult Party Cartoon) as Tiffany Turlington
  • Elmyra (from Tiny Toon Adventures) as Sandy Carington