- Bruce Banner as Stan Marsh
- The Hulk as Satan
- Betty Ross as Linda Stotch
- Emil Blonsky as Eric Cartman
- Samuel Sterns as Kyle Broflovski
- Dr. Leonard Samson as Kenny McCormick
- General "Thunderbolt" Ross as Jesus Christ
- Tony Stark as Chef (uncredited cameo at the end of the film)
- and more
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