• Elroy Jetson as Mario
  • Astro the Dog as Luigi
  • Judy Jetson as Peach
  • Orbitty as Yoshi
  • George Jetson as Wario
  • Jane Jetson as Daisy
  • Mr. Cogswell as Waluigi
  • Arthur Spacely as Toad
  • Zero the Dog as Boo
  • The Gripfather as Koopa Kid
  • Henry Orbit as Donkey Kong
  • Mr. Spacely as Bowser
  • Kenny as Red Koopa Kid
  • Irvin as Green Koopa Kid
  • Jimmy as Blue Koopa Kid
  • Montague Jetson as Eldstar
  • Miss Galaxy as Misstar
  • George's Mother as Mamar
  • Mugsy Megatron as Skolar
  • Knuckles Nuclear as Muskular
  • Jet Streamer as Klevar
  • Lenny Laser as Kalmar

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