- Jane Jetson as Blossom
- Judy Jetson as Bubbles
- Rosie the Robot Maid as Buttercup
- Montague Jetson as Professor Utonium
- Henry Orbit as The Mayor
- Emily Scopes as Sara Bellum
- Mr. Spacely as Mojo Jojo
- Mr. Cogswell as HIM
- George Jetson as Brick
- Elroy Jetson as Boomer
- Astro the Dog as Butch
- Mrs. Spacely as Sedusa
- Mrs. Meltdown as Princess Morbucks
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