• Elroy Jetson as Mario
  • Astro the Dog as Luigi
  • Judy Jetson as Peach
  • Orbitty as Toad
  • Jane Jetson as Rosalina
  • George Jetson as Captain Toad
  • Mr. Spacely as Bowser/Meowser
  • Rosie the Robot Maid as Green Sprixie
  • Mrs. Spacely as Yellow Sprixie
  • Mrs. Meltdown as Blue Sprixie
  • Miss Galaxy as Orange Sprixie
  • Melissa as Pruple Sprixie
  • George's Mother as Cyan Blue Sprixie
  • Jane's Mom as Red Sprixie Princess
  • Mugsy Megatron as Motley Bossblob
  • Lenny Laser as Boom Boom
  • Emily Scopes as Pom Pom
  • Sneak as King Hissocrat
  • Skata-Hara as Queen Hissocrat
  • The Gripfather as Boss Brolder
  • Mr. Cogswell as King Ka-Thunk

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