- Sam Spade as Homer Simpson
- Brigid O'Shaughnessy as Marge Simpson
- Iva Archer as Maggie Simpson
- Joel Cairo as Bart Simpson
- Lt. of Detectives Dundy as Mayor Joe Quimby
- Effie Perrine as Sherri
- Kasper Gutman as Ned Flanders
- Detective Tom Polhaus as Barney Gumble
- Miles Archer as Dr. Julius Hibbert
- Wilmer Cook as Moe Syzlak
- Luke as Mr. Burns
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