- The Queen as Maude Flanders
- Prime Minister Tony Blair as Homer Simpson
- Prince Philip as Mayor Joe Quimby
- Cherie Blair as Marge Simpson
- Charles, Prince of Wales as Officer Lou
- Robin Janvrin as Bart Simpson
- Queen Elizabeth as Allison Taylor
- Stephen Lamport as Dr. Julius Hibbert
- Alastair Campbell as Waylon Smithers, Jr.
- Lord Airlie as Principal Seymour Skinner
- Equerry as Moe Syzlak
- Janbrin's Secretary as Maggie Simpson
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