- Max as Jack
- Gru (from Despicable Me) as Andrew Ryan
- Mel as Atlas
- Duke as Big Daddy
- Agnes (from Despicable Me) as Little Sister
- Lucy (from Despicable Me 2) as Brigid Tenenbaum
- Snowball as Frank Fortaine
- Marty (from Madagascar) as Booker DeWitt
- Chloe as Elizabeth
- Pops as Zachary Hale Comstock
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