Cast[]
- Max as Cat
- Duke as Dog
- Silas Ramsbottom (from Despicable Me 2) as Winslow
- Snowball as Rancid Rabbit
- Dr. Nefario (from Despicable Me) as Cliff
- Vector (from Despicable Me) as Lube
- Kailani (from Journey 2: The Mysterious Island) as Shriek
- Gidget as Tallulah
- Buddy as Randolph Grant
- Chloe as CatDog's Mom
- Norman as CatDog's Dad
- Mr. O'Hare (from Dr. Seuss' The Lorax) as Cliff's Dad
- Sweetpea as Lola
- Gru (from Despicable Me) as Mr. DuBois
- The Once-ler's Mom (from Dr. Seuss' The Lorax) as Mrs. DuBois
- Max and Duke's Owner as Ellie Mae Sue
- Anges (from Despicable Me) as Princess
- Hank (from Journey 2: The Mysterious Island) as Amazing Ray
- Sean (from Journey 2: The Mysterious Island) as Wise Guy of the Mountain