- Vector (from Despicable Me) as The Grinch
- Max as Max
- Kailani (from Journey 2: The Mysterious Island) as Cindy Lou Who
- Duke as Lou Lou Who
- Chloe as Betty Lou Who
- The Once-ler's Mom (from Dr. Seuss' The Lorax) as Martha May Whovier
- Dr. Nefario (from Despicable Me) as Mayor Augustus May Who
- Snowball as Drew Lou Who
- Hank (from Journey 2: The Mysterious Island) as Stu Lou Who
- Gru (from Despicable Me) as Whobris
- Max and Duke's Owner as Clarnella
- E.B. (from HOP) as Buddy the Elf (from ELF)
- Silas Ramsbottom (from Despicable Me 2) as Old Man Marley (from Home Alone)
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