- Duke as Percy Jackson
- Chloe as Annabeth Chase
- Snowball as Dionysus
- Max as Grover Underwood
- Mel as Polyphemus
- Gru (from Despicable Me) as Tyson
- Dr. Nefario (from Despicable Me) as Hermes
- Max and Duke's Owner as Thalia Grace
- E.B. (from HOP) as Zeus
- Hank (from Journey 2: The Mysterious Island) as Chiron
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