• Max as Homer
  • Gidget as Marge
  • Mel as Bart
  • Chloe as Lisa
  • Sweetpea as Maggie
  • Dr Nefario (from Despicable Me) as Grandpa Abe
  • Gru (from Despicable Me) as Ned Flanders
  • Lucy (from Despicable Me 2) as Maude Flanders
  • Snowball as Mr. Burns
  • Buddy as Waylon Smithers
  • Marty (from Madagascar) as Chief Wiggum
  • Minions (from Despicable Me) as Ralph Wiggum
  • Eduardo (from Despicable Me) as Krusty the Clown
  • Pops as Moe
  • Duke as Barney
  • Vector (from Despicable Me) as Snake Jailbird

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