- Bart as Hiro Hamada
- Barney as Baymax
- Homer as Tadashi
- Principal Skinner as Wasabi-No-Ginger
- Marge as Honey Lemon
- Luanne Van Houten as GoGo Tomago
- Krusty the Clown as Fred
- Mr. Burns as Robert Callaghan
- Maude Flanders as Cass
- Superintendent Chalmers as Alistair Krei
- Sideshow Bob as Yokai
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