- Homer as Gnomeo
- Marge as Juliet
- Lenny as Benny (they are both ending names with letter Y)
- Lisa as Nanette
- Edna Krabappel as as Mrs. Montague
- Principal Skinner as Mr. Capulet
- Bart as Shroom
- Carl as Featherstone
- Sideshow Bob as Terrafriminator
- Smithers as Fawn
- Mr. Burns as Tybalt (Homer cannot be Tybalt because Tybalt is evil and Homer is good)
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