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- Homer as Hercules
- Marge as Megara
- Mr.Burns as Hades
- Snake Jailbird as Pain
- Dolph as Panic
- Moe as Philoctetes
- Numbuh 1(from Codename: Kids Next Door) as Zeus
- Numbuh 5(from Codename: Kids Next Door) as Hera
- Rolf(from Ed, Edd n Eddy) as Hermes
- Nazz and Kevin(from Ed, Edd n Eddy) as Herc's earthly parents