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- Homer as Indiana Jones
- Grandpa Abe as Henry Jones Sr.
- Marge as Marion Ravenwood
- Lisa as Willie Scott
- Lenny as Short Round
- Principal Skinner as Sallah
- Jessica Lovejoy as Elsa Schneider
- Edna Krabappel as Irina Spalko
- Mr. Burns as Rene Belloq
- Sideshow Bob as Mola Ram