• Ralph as Little Bill
  • Bart as Bobby
  • Lisa as April
  • Mona as Alice The Great
  • Homer as Big Bill
  • Marge as Brenda
  • Maggie as Baby Jamal
  • Milhouse as Andrew
  • Luann Van Houten as Andrew's Mom
  • Dr. Hibbert as Dr. Clinkscales
  • Bill Cosby as Himself
  • Edna Krabappel as Miss Murray
  • Laura Powers as Isabel
  • Bashir as Dorado
  • Nelson as Michael Rhiley
  • Janey as Fuchsia
  • Tumi as Kiku
  • Cookie Kwan as Kiku's Mom
  • Carl as Al Glover
  • Üter as Monty
  • Helen Lovejoy as Vanessa Glover
  • Kent Brockman as Mr. Rojas
  • Maude Flanders as Mrs. Shaprio
  • Santa's Little Helper as Lito
  • Dewey Largo as Mr. Williams
  • Seymour Skinner as Mr. Terry
  • Rainer Wolfcastle as Captain Brainstorm

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