Cast
- Homer as The Annoying Orange
- Lenny as Apple
- Principal Skinner/Barney as Bananas
- Abe as Kiwi
- Carl as Lemon
- Marge as Strawberry
- Bart as Pear
- Nelson and Jimbo as Sushi
- Luann Van Houten as Cheese
- Kirk Van Houten as Mystery Potato
- Maude Flanders as Carrot
- Homer's Half Brother as Tomato
- Sonic (from Sonic) as Mario
- Stan Marsh (from South Park) as Football
- Ned Flanders as Ball
- Trevor (from Sonic) as Pumpkins
- Disco Stu as Sandy Claus
- Henry (from TTTE) as Ghost
- Rod/Todd as Pac-Man
- Mr. Burns as Pineapple
- Sideshow Mel as Grapefruit
- Lisa as Grape
- Jimmy Cricket (from Pinocchio) as Broccoli Leader
- Billy's toys (from Tin Toy) as Vivisector 9000
- Maggie as Avacado
- Ike Broflovski (from South Park) as Avacado Pit
- Moe as Walnut
- Sideshow Bob as Pepper
- Dr. Nick as Bonsai Tree
- Edna Krabappel as Onion
- Marmaduke (from Marmaduke 2010 movie) as Grandpa Lemon
- Wendy Testaburger (from South Park) as Eggplant
- Snake as Jigsaw
- Lou as the Annoying Orange 2
- Big ted (from Play School) as Crabapple
- Groundskeeper Willie as Midget Apple
- Krusty as Watermelon
- Comic Book Guy as Grand Finale
- A Clown (from A Smosh Video: SELLING OUT!?) as Nut Cracker
- Boxman and Anthony (from Smosh) as Squirrel and Crab
- Fat Tony as the Onion Ring
- Bumblebee Man as Passion Fruit
- Kearney/Dolph as Fred Figglehorn
- Ralph Wiggum as Liam the Leprechuan
- Superintendent Chalmers as Dane Boedigheimer
- Computer (from The Brave Little Toaster) as Daneboe's Knife
- Boots (from Dora the Explorer) as Green Apple
- Radio (from The Brave Little Toaster) as Red Delicous
- Lampy (from The Brave Little Toaster) as Golden Delicous
- Faucet (from The Brave Little Toaster) as Granny Smith
- Woody (from Toy Story) as Angel Orange
- Buzz Lightyear (from Toy Story) as Devil Orange
- The Fireman Sam, Postman Pat and Superted Characters as Orange Group
- Prefessor Frinks as Chocolate
- Eric Cartman (from South Park) as Craham Cracker
- Chief Wiggum as Marshmallow
- Milhouse Van Houten as Charlie the Drunk Guinea Pig
- Patty/Selma as Lady Pasta
- Eddie as Cucumber
- Tessie Bear (from Noddy's Toyland Adventures) as Grapefruit's Sister
- Noddy (from Noddy's Toyland Adventures) as Grapefruit's Second Cousin
- Bert Monkey (from Noddy's Toyland Adventures) as Grapefruit's Grandpa
- Mr. Tubby Bear (from Noddy's Toyland Adventures) as Grapefruit's Mailman
- Plugsy (from The Brave Little Toaster) as Cabbage
- Martin as Celery
- Bullhorn (from The Brave Little Toaster)/Hank Hill (from King of the Hill)/Vector (from Sonic)/Celing Fan (from The Brave Little Toaster) as Blackberry
- Helen Lovejoy as Princess Peach
- The Sea Captain as Toad
- Elmo St. Peters (from The Brave Little Toaster) as Bowser
- Reverend Lovejoy, Peter (from Family Guy) and Apu as Party Platter
- Mr Smithers as Voice
- Mayor Quimby as Spider
- John as Lime
- Lois (from Family Guy) as Wee Pony
- The Elephants (from The Jungle Book) as Orange's One Million Clones
- Mrs. Testaburger (from South Park) as Peaches (from Ice Age: Continetal Drift)
- Mr. Testaburger (from South Park) as Dr. Interwebs
- Jasper as Youtube
- Yes Guy as Ginger
- The Huntsman (from Snow White) as Blender
- Stromboli (from Pinocchio) as Grater
- The Toy Monkey (from Toy Story 3) as Gorilla
- TBA character as Knife's Talk
- Mr. Plod (from Noddy's Toyland Adventures) as Evil Orange
- Hans Moleman as Steve the Strawberry
- Metroman (from Megamind) as Future Orange