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The Simpsons/The Hitchhiker's Guide To The Galaxy (2005) is a parody with The Hitchhiker's Guide To The Galaxy (2005) sounds and The Simpsons clips
- Principal Skinner as Arthur Dent
- Barney as Ford Prefect
- Bart as Zaphod Beeblebrox
- Edna Krabappel as Trillian
- Abe as Slartibartfast
- Rod/Todd as Marvin
- Ned Flanders as Questular Rontok
- Maude Flanders as Deep Thought
- Stan Marsh (from South Park) as Narrator
- Homer's Half Brother as Humma Kavula
- Homer, Lenny, Marge, Lisa, Groundskeeper Willy, Chief Wiggum and Carl as Dolphins
- Mayor Quimby as The Whale