- Lisa Simpson as Dorthy
- Marge Simpson as Aunt Em
- Homer Simpson as Uncle Henry
- Helen Lovejoy as Glinda the Good Witch
- Various Springfielders as the Mucnchkins
- Moe as the Tin Man
- Otto as the Lion
- Barney as the Scarecrow
- Mr. Burns as the Miss Gultch/Wicked Witch
- Mr. Smithers as the Head Flying Monkey
- Comic Book Guy as the Door Guard
- Krusty the Klown as Proffesor Marvel/the Wizard
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