Carly Shay, Sam Puckett, Freddie Benson, Spencer Shay, Gibby, (along with Mac, Bloo, Scrooge McDuck, and their friends) have traveled to London, England and met Pongo, Perdita, and their 15 puppies. They soon learned that the puppies were stolen by Jasper and Horace. They have been hired by the most outrageous Disney villain of all, Cruella De Vil, whom Nevel Papperman, Admiral Zarhk, Demetri, and Evon work for. Can Carly Shay and the others help Pongo and Perdita get the puppies back to London before the villains do any harm on them? You be the judge.
Mac, Bloo, Wilt, Eduardo, Coco, Mr. Herriman, Frankie Foster, Ludwig Von Drake, Drake & Josh, Bagheera, Buzzy, Ziggy, Flaps, Dizzy, Baloo, Basil of Baker Street, Dr. Dawson, Bill, Aldo, The Naked Brothers Band, Timothy Q. Mouse, Jim Crow and his Crow Brothers, Jock, Trusty, Admiral Zarhk, Manny, Ellie And the Subspace Empire guest star in the film.
Dumbo, The Great Mouse Detective, The Jungle Book, 101 Dalmatians, and Lady and the Tramp were all made by Disney.
Like in Pooh's Adventures of 101 Dalmatians, Simba, Timon and Pumbaa's Adventures of 101 Dalmatians, and Yogi Bear's Adventures of 101 Dalmatians, Mac, Bloo,Jackie Khones, Carly Shay, Sam Puckett will be kidnapped with Pongo and Perdita's 15 puppies by Jasper and Horace.